Mendus and NorthX Biologics to enter into strategic cell therapy manufacturing alliance supported by new investor Flerie

Mendus and NorthX Biologics to enter into strategic cell therapy manufacturing alliance supported by new investor Flerie

Mendus AB (“Mendus” publ; IMMU.ST), a biopharmaceutical company focused on immunotherapies addressing tumor recurrence, today announces that it has entered into a manufacturing alliance with NorthX Biologics AB (“NorthX”). NorthX is a Contract Development and Manufacturing Organization (CDMO) and serves as the National Swedish Innovation Hub for the GMP manufacture of biologics used in vaccines, gene therapy and other advanced therapy medicinal products (ATMPs). Mendus and NorthX will co-establish cell therapy manufacturing capabilities in Sweden, which will be used for late-stage development and commercial manufacturing of Mendus’ lead asset vididencel.

In conjunction with the NorthX collaboration, Mendus has entered into an agreement with Flerie Invest AB (“Flerie”), a leading Swedish investment firm. Flerie will initially invest SEK 90 million in Mendus to support the NorthX alliance. With the investment, Mendus and NorthX will collaborate to realize a cell therapy facility to be used for the large-scale manufacturing of Mendus’ lead program vididencel. The planned investment is scheduled to cover all necessary activities until Q2 2025, including adjustments to current NorthX facilities, tech transfer of the vididencel manufacturing process and manufacturing of vididencel batches for a pivotal-stage clinical trial. Following the successful completion of the financing transaction, Flerie will join Van Herk Investments and the Fourth Swedish National Pension Fund (AP4) as a major Mendus shareholder. Ted Fjällman, Chief Executive Officer at Flerie, is expected to join Mendus’ Board of Directors, subject to shareholder approval. The collaboration with NorthX and the investment by Flerie are part of a larger financing transaction of Mendus, which will be announced through a separate press release, and is conditional upon approval by an Extraordinary General Meeting, expected to be held on July 10, 2023.

Mendus has established a rich pipeline of innovative cell-based immunotherapy product candidates focused on delaying or preventing tumor recurrence, the main cause of death of cancer patients today. Vididencel is currently being evaluated in the ADVANCE II Phase 2 clinical study in Acute Myeloid Leukemia (AML) with patients in long-term follow up. Interim results on the primary and secondary endpoints of the study have demonstrated vididencel’s potential to treat minimal residual disease, improve the immune status of patients, and result in relapse-free and overall survival benefits. The company is preparing to advance vididencel into late-stage and pivotal-stage development with a second Phase II in AML maintenance, a combination study with standard of care, planned for H2 2023. In addition to hematological malignancies, Mendus is evaluating vididencel in ovarian cancer to translate the therapeutic strategy into the treatment of solid tumors.

“Establishing large-scale manufacturing is a key element of our development strategy for vididencel. The alliance with NorthX as Sweden’s emerging center of excellence for manufacturing of this drug class, supported by an investment by Flerie, is a major step for Mendus in this regard, as it brings together the required funding and the opportunity to establish a dedicated facility to manufacture vididencel for the next stage of clinical development and, eventually, commercialization,” commented Erik Manting, PhD, Chief Executive Officer of Mendus.

“Visiting the team on-site showed that NorthX uniquely combines innovation in process development and the industrial know-how to scale-up GMP manufacturing of ATMPs. This is key for the stage we are now entering for the large-scale manufacturing of vididencel. Additionally, Flerie’s active ownership model and their team’s operational experience having built Recipharm will be invaluable to us, as is the commitment and support from the Swedish government to build up world-class manufacturing expertise in the country,” said Leopold Bertea, PhD, Chief Technology Officer of Mendus.

“This strategic alliance not only paves Mendus’ path to commercializing vididencel for the benefit of cancer patients, but ensures NorthX strenghtens its positioning as the premier GMP manufacturing hub for advanced therapies in the Nordics, attracting regenerative medicine innovators worldwide. We are proud to be working with Mendus to hone both teams’ skills in this rapidly developing area of cell therapies,” said Helena Strigård, Chief Executive Officer of NorthX.

“Mendus’ approach to develop vididencel as a cancer maintenance therapy has the potential to prolong survival for many patients, based on an impressive doubling of median overall survival compared to the current standard of care in the most recent Phase 2 read-out in AML. The Mendus team has correctly focused on the science and good clinical trial design, and we are now happy to join very competent investors Van Herk and AP4 to help Mendus scale manufacturing together with NorthX and translate their cutting edge oncology, vaccine and cell therapy competence into products available to patients worldwide,” commented Ted Fjällman, Chief Executive Officer at Flerie.


Mendus is dedicated to changing the course of cancer treatment by addressing tumor recurrence and improving survival outcomes for cancer patients, while preserving quality of life. We are leveraging our unparalleled expertise in allogeneic dendritic cell biology to develop an advanced clinical pipeline of novel, off-the-shelf, cell-based immunotherapies which combine clinical efficacy with a benign safety profile. Based in Sweden and The Netherlands, Mendus is publicly traded on the Nasdaq Stockholm under the ticker IMMU.ST.


Flerie is an active long-term global biotech and pharma investor based in Stockholm and London managing a portfolio of over 30 companies in Europe, Israel and the US. Flerie’s evergreen investment strategy, operational expertise and network enables pioneering technologies in the drug development and services space to advance on their path to treating patients and commercialisation. Flerie was founded in 2011 by Thomas Eldered, who also co-founded and built Recipharm to be one of the world’s top five pharmaceutical contract manufacturers. For more information, please visit

Meeting on the Mesa

Come and meet us ! 

The Cell & Gene Meeting on the Mesa is the sector’s foremost annual conference bringing together senior executives and top decision-makers in the industry to advance cutting-edge research into cures. Tackling the commercialization hurdles facing the cell and gene therapy sector today, this meeting covers a wide range of topics from clinical trial design to alternative payment models to scale-up and supply chain platforms for advanced therapies.

Helena Strigård appointed as new CEO of rapidly expanding NorthX Biologics

The Board of NorthX Biologics (“NorthX”) has appointed Helena Strigård as the new CEO. She joins NorthX from her role as Director General for the Swedish life science industry organization, SwedenBIO. Helena will lead NorthX’s continued expansion in the development and production of advanced biologics. Ted Fjällman, current CEO of NorthX and Partner of the Company’s  main investor, Flerie Invest, will continue to support the company as a member of the Board.

NorthX has one of Northern Europe’s largest manufacturing capacities for clinical material in the forms of plasmid DNA, recombinant proteins, cell banking, and related gene therapy services. Since the takeover in October 2021, NorthX has recruited a Leadership Team, Sales Team and Board for the rapidly growing company. In addition to the GMP-certified production facility in Matfors, the Company is now establishing itself on the Karolinska University Hospital’s campus in Stockholm and is developing an innovation hub for ATMPs and advanced therapeutics in collaboration with Vinnova, the Swedish Innovation Agency.

NorthX is establishing itself as a partner of choice in the Nordics for cell and gene therapy companies that need GMP manufacturing services. Now the company wants to shift gears to become a global player with a continued strong focus on individual projects and customers, in a spirit of partnership according to the motto “Journey together”. During the first year, Ted Fjällman has had the role of interim CEO and during this time has successfully transitioned NorthX into a Company with all the necessary functions to develop internationally. With that foundation, the Company has now appointed a new CEO, Helena Strigård to continue the Company’s growth. Helena has broad experience from the Ministry of Finance and Vinnova and has taken the organization SwedenBIO through a period of rapid expansion, which saw the membership income doubled.

“NorthX has in a short time built up a broad capacity for advanced biologics. I am excited to be joining at this stage in the Company’s growth and will use all my industry know-how and global network to ensure that we succeed,” said Helena Strigård. 

“Under Helena’s leadership, SwedenBIO has taken its place on international arenas to the benefit of the entire industry. NorthX will be able to leverage that driving force to achieve international impact. As a Board we look forward to working with her in order to achieve this important goal. I would like to take this opportunity to thank Ted Fjällman for his successful efforts as interim CEO; he has laid an important foundation for continued success for NorthX and I am grateful that he continues to serve on the Company’s Board”, added Thomas Eldered, chairman of the board of NorthX.

Helena takes up her role on the 6th October.

For further information please email NorthX at

Drug development of today and the future

What: Seminar
Where: Klara Strand, Klarabergsviadukten 90, Stockholm
When: 19th October

We are organizing a seminar on “Drug development of Today and the Future” in collaboration with Abera Biosciences AB, Testa Center, RISE Research Institutes of Sweden, STUNS Life science and Business Sweden on the 19th of October 2022. 

We are using this opportunity to invite you to participate to this event.

Be present to hear our own Eva-karin Gidlund and other eminent speakers engaged in the development of drugs talking about opportunities, problems and practical examples of the field where innovative ways of collaboration and new acquired skills were essential to surmount hurdles associated with our branch’s new demands.

The future is coming in fast, with it new challenges arise for all of us who are active in our industry. This seminar is intendent to be a platform for networking, exchange of ideas, best practices and possible solutions.

We eagerly await your participation in the seminar!

Preliminary program:

15:00 – Introduction
15:05 – Jesper Hedberg (Testa Center)
15:15 – Matti Sällberg (pre – GMP facillity)
15:25 – Eva-karin Gidlund (NorthX Biologics)
15:35 – Anna Ridderstad Wollberg (RISE)
15:45 – Coffee break
16:00 – Maria Alriksson (Abera Biosciences)
16:15 – Angelica Loskog (Lokon Pharma)
16:30 – Charlotte af Klercker & Britta Stenson (Business Sweden, followed by Q&A and discussions)
17:00 -19:00 – Mingle with snacks

Click here to register!

BIO International Convention

June 13-16, 2022・San Diego, CA

We are excited to be exhibiting at BIO USA this year.  Come stop by our booth (#1054) or contact us to schedule a meeting. 

The BIO International Convention is back and in-person. Join us June 13-16 in San Diego, California for four exciting days of networking, programming, and partnering opportunities that will shape the future of our industry and celebrate the scientific discoveries transforming our world.

ATMP world tour 2022 topic #8 ’CDMO roles in ATMP development’.

“We welcome Dave Smith from Akron Bio and Ola Tuvesson from NorthX Biologics to present and discuss the critical functions of CMOs and their role in managing the challenges of adapting from traditional biologics to ATMPs.”